abstract：OBJECTIVE:The aim was to investigate the ventricular/vascular coupling of the intact right heart under conditions of normal operation and acute pulmonary hypertension. METHODS:Right ventricular contractility was obtained by calculating the end systolic pressure-volume relationship (Ees) and the effective pulmonary art...

journal_title：Cardiovascular research

authors： Fourie PR,Coetzee AR,Bolliger CT

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:The aim was to validate echocardiographic assessment of acute changes of left ventricular stroke volume in normal rats. METHODS:By transthoracic use of a 7.5 MHz ultrasonic transducer, the left ventricular dimensions were determined before and during rapid atrial pacing and saline infusion in seven Wistar ra...

journal_title：Cardiovascular research

authors： Nakamura T,Matsumuro A,Kuribayashi T,Matsubara K,Shima M,Shimoo K,Katsume H,Nakagawa M

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:The aim was to study L type calcium current alterations in relation to the action potential lengthening induced by hypertrophy in isolated cardiomyocytes from the right ventricle of ferret. METHODS:Chronic pulmonary artery constriction was established in adult male ferrets under anaesthesia. Sham operated an...

journal_title：Cardiovascular research

authors： Bouron A,Potreau D,Raymond G

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:The aim was to study the effect of thyroid hormone on collagen gene expression in the myocardium of the tight skin mouse (TSK), a genetic model of myocardial fibrosis. METHODS:Heterozygous male (TSK/+) (n = 20) and normal (+/+) homozygous mice (n = 20), 1.5-2 months old of the C57 BL/6 strain were studied. V...

journal_title：Cardiovascular research

authors： Yao J,Eghbali M

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate in a minipig model of acute myocardial infarction the cardioprotection provided by the beta adrenoceptor blocking and vasodilating activities present in carvedilol; comparison was made to the pure beta adrenoceptor antagonist, propranolol. METHODS:Experiments were performed in 25 Yuca...

journal_title：Cardiovascular research

authors： Bril A,Slivjak M,DiMartino MJ,Feuerstein GZ,Linee P,Poyser RH,Ruffolo RR Jr,Smith EF 3rd

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

journal_title：Cardiovascular research

authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

journal_title：Cardiovascular research

authors： Ibuki C,Hearse DJ,Avkiran M

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the effect of doxorubicin on spontaneous cyclic Ca2+ release from the sarcoplasmic reticulum of skinned fibres, as measured by isometric tension development in EGTA free, Ca2+ free solution. METHODS:Experiments were done on fragments of papillary muscles from the right ventricles of gu...

journal_title：Cardiovascular research

authors： Asayama J,Yamahara Y,Tatsumi T,Miyazaki H,Inoue M,Omori I,Inoue D,Nakagawa M

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:The aim was to establish whether the duration of coronary ischaemia and coronary ischaemia with reperfusion selectively reduced the magnitude of relaxation mediated by endothelium dependent relaxing factor (EDRF) in response to thrombin, compared with relaxation produced by acetylcholine and calcimycin. METH...

journal_title：Cardiovascular research

authors： Winn MJ,Ku DD

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the roles of left atrial pressure and ventricular function in the determination of early diastolic filling. METHODS:Various grades of ventricular dysfunction were made in 12 mongrel dogs by coronary microembolization under pentobarbitone anaesthesia. Left atrial pressure was altered by...

journal_title：Cardiovascular research

authors： Nakatani S,Beppu S,Miyatake K,Nimura Y

更新日期：1992-02-01 00:00:00

abstract：:Although substantial information has accumulated over the past decade, many gaps remain in our understanding of the regulation of contractility and modulation of inotropic responsiveness in the developing heart. There are several important problems facing investigators in the field of developmental cardiology. Respons...

journal_title：Cardiovascular research

authors： Artman M

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

journal_title：Cardiovascular research

authors： Wright G

更新日期：1991-11-01 00:00:00

abstract：STUDY OBJECTIVE:Afterload reduction is known to reduce regurgitant flow in patients with aortic regurgitation. Both arterial compliance and total peripheral resistance are determinants of afterload. The aim of this study was to evaluate the influence of arterial compliance and total peripheral resistance on the regurgi...

journal_title：Cardiovascular research

authors： Slørdahl SA,Piene H

更新日期：1991-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if the adaptational process of the cardiac calcium channel to pressure overload observed in rat heart also occurs in species characterised by a higher sensitivity to external calcium than in the rat. This adaptation occurs via a maintained density of dihydropyridine receptors an...

journal_title：Cardiovascular research

authors： Primot I,Mayoux E,Oliviero P,Charlemagne D

更新日期：1991-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate observed differences in beta adrenergic and apparent non-beta-adrenergic binding of (-)[125I]-iodocyanopindolol (125I-ICYP). DESIGN:Binding parameters for several beta adrenergic agonists and antagonists were examined in radioligand binding assay, using 125I-ICYP as radioliga...

journal_title：Cardiovascular research

authors： Bjørnerheim R,Golf S,Hansson V

更新日期：1991-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare platelet function in diabetic and non-diabetic survivors of acute myocardial infarction and to relate it to an index of free radical activity in these patients. DESIGN:In vivo and in vitro indices of platelet function and diene conjugate molar ratios were measured in diabetic and...

journal_title：Cardiovascular research

authors： Hendra TJ,Wickens DG,Dormandy TL,Yudkin JS

更新日期：1991-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate whether basal coronary vascular tone and myocardial perfusion depend upon endothelial nitric oxide (NO) synthesis. DESIGN:Myocardial blood flow and vascular resistance of the left and right ventricles were studied before and after intravenous infusions of either NG-nitro-L-ar...

journal_title：Cardiovascular research

authors： Benyó Z,Kiss G,Szabó C,Csáki C,Kovách AG

更新日期：1991-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to quantify the changes in placental blood flow and combined ventricular output with gestational age in normal human fetuses to determine the percentage of total cardiac output that placental blood flow represented, and whether this changed with age. DESIGN:Two dimensional echocardiographic...

journal_title：Cardiovascular research

authors： Sutton MG,Plappert T,Doubilet P

更新日期：1991-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the effects of long-term treatment with an alpha 1 blocker, bunazosin hydrochloride, on blood pressure, heart weight, myocardial contractility, and ventricular myosin isoenzyme pattern in spontaneously hypertensive rats (SHR). DESIGN:Bunazosin hydrochloride was given orally i...

journal_title：Cardiovascular research

authors： Takeda N,Nakamura I,Ohkubo T,Iwai T,Tanamura A,Nagano M

更新日期：1991-07-01 00:00:00

abstract：STUDY OBJECTIVE:Compensatory mechanisms of the left ventricle for volume overloading caused by acute aortic regurgitation and associated changes in physiological properties of the aorta were studied in rabbits. DESIGN:Aortic regurgitation was produced by aortic valve perforation, and haemodynamic measurements were per...

journal_title：Cardiovascular research

authors： Wainai Y

更新日期：1991-06-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the influence that centrally administered angiotensin-II has on the intrarenal renin-angiotensin system and renal sympathetic nerve activity. DESIGN:Renal responses to centrally administered angiotensin-II (10 micrograms) or saralasin (50 micrograms) were measured in anaesthetis...

journal_title：Cardiovascular research

authors： Weekley LB

更新日期：1991-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：STUDY OBJECTIVE:It has been suggested that oxygenation of the isolated, crystalloid perfused, Langendorff rabbit heart is inadequate and that consequent hypoxia limits mechanical performance. The isolated working rabbit heart, which has a higher oxygen requirement than the Langendorff preparation, was used to investiga...

journal_title：Cardiovascular research

authors： Murashita T,Kempsford RD,Hearse DJ

更新日期：1991-03-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the thrombolytic efficacy of recombinant double chain tissue plasminogen activator (Duteplase, t-PA) given as a single intravenous bolus versus an infusion in a canine model of coronary arterial occlusion/reperfusion. DESIGN:Coronary arterial thrombi were induced by a copper coi...

journal_title：Cardiovascular research

authors： Longridge DJ,Follenfant MJ,Ford AJ

更新日期：1991-03-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the protective effect of verapamil during myocardial ischaemia and reperfusion. DESIGN:In vivo phosphorus-31 (31P) magnetic resonance spectroscopy was performed on rats pretreated with verapamil (mg.kg-1 intraperitoneal) and controls during a 45 min left coronary artery occlusio...

journal_title：Cardiovascular research

authors： Wolfe CL,Donnelly TJ,Sievers R,Parmley WW

更新日期：1991-02-01 00:00:00

abstract：STUDY OBJECTIVE:Incidence of spontaneous cardiac arrhythmias and inducibility of ventricular arrhythmias in the cardiomyopathic hamster, BIO 14.6 strain, were examined. DESIGN:A 3 min electrocardiogram (ECG) was recorded weekly to 50 weeks of age. Programmed ventricular stimulation was then performed with single and d...

journal_title：Cardiovascular research

authors： Hano O,Mitsuoka T,Matsumoto Y,Ahmed R,Hirata M,Hirata T,Mori M,Yano K,Hashiba K

更新日期：1991-01-01 00:00:00

abstract：STUDY OBJECTIVE:Protective effects of nipradilol, a newly synthesised vasodilating beta adrenoceptor antagonist, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine were determined by coronary arteriography and compared in vivo in pigs. DESIGN:Acetylc...

journal_title：Cardiovascular research

authors： Kawamura A,Fujiwara H,Ishida M,Takemura G,Kida M,Uegaito T,Tanaka M,Kawai C

更新日期：1990-12-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether taurine influences the membrane surface charges in cardiac muscle. DESIGN:Screening of the negative charges at the outside surface of the membrane results in a shift of the steady state inactivation of the sodium system towards less negative potentials. This feature was...

journal_title：Cardiovascular research

authors： Dumaine R,Schanne OF,Ruiz-Petrich E

更新日期：1990-11-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the arrhythmogenic properties of several sympathomimetic amines and their antagonism by adrenergic blocking drugs. DESIGN:Arrhythmia was induced by the investigated drugs, injected intravenously: adrenaline (ADR); noradrenaline (NA); phenylephrine (PE); isoprenaline (IP); ter...

journal_title：Cardiovascular research

authors： Oppenheimer E,Akavia E,Shavit S,Korczyn AD

更新日期：1990-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to fibrosis. DESIGN:In 72 male Wistar rats (250-350 g) the transient stimul...

journal_title：Cardiovascular research

authors： Silver MA,Pick R,Brilla CG,Jalil JE,Janicki JS,Weber KT

更新日期：1990-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether depressed myocardial contractility is responsible for the decline in stroke volume that occurs with cardiac tamponade. DESIGN:Left ventricular contractile performance was assessed before and after beta adrenergic blockade using the end systolic pressure-volume relation,...

journal_title：Cardiovascular research

authors： Johnston WE,Vinten-Johansen J,Klopfenstein HS,Santamore WP,Little WC

更新日期：1990-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. DESIGN:Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and p...

journal_title：Cardiovascular research

authors： Moe GW,Angus C,Howard RJ,De Bold AJ,Armstrong PW

更新日期：1990-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate. DESIGN:Diastolic left atrial and left ventricular pressures were recorded at high sensitivity (40 mm Hg = 10 mm recorded deflection) ...

journal_title：Cardiovascular research

authors： Carmeliet P,Aubert A,Van de Werf F,De Geest H

更新日期：1990-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium. DESIGN:The suction period preceding the...

journal_title：Cardiovascular research

authors： Boekstegers P,Diebold J,Weiss C

更新日期：1990-06-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, pr...

journal_title：Cardiovascular research

authors： Stefanon I,Vassallo DV,Mill JG

更新日期：1990-03-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to reassess the role of reactive oxygen species in causing reperfusion arrhythmias, which they might do either by directly generating free oxygen radicals or by using scavengers of free oxygen radicals. DESIGN - Ventricular arrhythmias were studied in isolated rat hearts (n =...

journal_title：Cardiovascular research

authors： Coetzee WA,Owen P,Dennis SC,Saman S,Opie LH

更新日期：1990-02-01 00:00:00

abstract：:STUDY OBJECTIVE - The objective was to measure platelet function in vivo (as cutaneous bleeding time), the role of catecholamines, and the effect of inhibiting thromboxane synthesis on bleeding time, in patients with myocardial infarction, unstable angina, and non-cardiac chest pain. DESIGN - Haemotological variables ...

journal_title：Cardiovascular research

authors： Kristensen SD,Bath PM,Martin JF

更新日期：1990-01-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to determine the changes in the beta adrenergic system induced by cardiac hypertrophy due to valvular aortic stenosis. DESIGN - Density of beta adrenoceptors, cardiac tissue noradrenalime concentrations, coronary blood flow (using radioactive microspheres), and haemodynamic v...

journal_title：Cardiovascular research

authors： Scholz PM,Upsher ME,Eliades D,Kedem J,Weiss HR

更新日期：1990-01-01 00:00:00

abstract：:We used the phase modulated rotating frame imaging technique to measure transmural distribution of phosphorus metabolites in 10 anaesthetised ventilated pigs using a double surface coil placed on the surface of the left ventricle. Anaesthesia was maintained in five animals with halothane, barbiturate and nitrous oxide...

journal_title：Cardiovascular research

authors： Rajagopalan B,Bristow JD,Radda GK

更新日期：1989-12-01 00:00:00